Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.
Identifieur interne : 000A82 ( Main/Exploration ); précédent : 000A81; suivant : 000A83Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.
Auteurs : Ivana D. Radojevi [Serbie] ; Zorica D. Petrovi ; Ljiljana R. Omi ; Dušica Simijonovi ; Vladimir P. Petrovi ; Dimitra Hadjipavlou-LitinaSource :
- Medicinal chemistry (Shariqah (United Arab Emirates)) [ 1875-6638 ] ; 2012.
Descripteurs français
- KwdFr :
- Antibactériens (), Antibactériens (pharmacologie), Antifongiques (), Antifongiques (pharmacologie), Antinéoplasiques alcoylants (), Antinéoplasiques alcoylants (pharmacologie), Bactéries à Gram négatif (), Bactéries à Gram négatif (croissance et développement), Bactéries à Gram positif (), Bactéries à Gram positif (croissance et développement), Champignons (), Champignons (croissance et développement), Chlorméthine (), Complexes de coordination (), Complexes de coordination (pharmacologie), Lipoxygenase (), Lipoxygenase (métabolisme), Platine (), Promédicaments (), Promédicaments (pharmacologie), Soja (), Soja (enzymologie), Tests de sensibilité microbienne.
- MESH :
- croissance et développement : Bactéries à Gram négatif, Bactéries à Gram positif, Champignons.
- enzymologie : Soja.
- métabolisme : Lipoxygenase.
- pharmacologie : Antibactériens, Antifongiques, Antinéoplasiques alcoylants, Complexes de coordination, Promédicaments.
- Antibactériens, Antifongiques, Antinéoplasiques alcoylants, Bactéries à Gram négatif, Bactéries à Gram positif, Champignons, Chlorméthine, Complexes de coordination, Lipoxygenase, Platine, Promédicaments, Soja, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Antifungal Agents (chemistry), Antifungal Agents (pharmacology), Antineoplastic Agents, Alkylating (chemistry), Antineoplastic Agents, Alkylating (pharmacology), Coordination Complexes (chemistry), Coordination Complexes (pharmacology), Fungi (drug effects), Fungi (growth & development), Gram-Negative Bacteria (drug effects), Gram-Negative Bacteria (growth & development), Gram-Positive Bacteria (drug effects), Gram-Positive Bacteria (growth & development), Lipoxygenase (chemistry), Lipoxygenase (metabolism), Mechlorethamine (chemistry), Microbial Sensitivity Tests, Platinum (chemistry), Prodrugs (chemistry), Prodrugs (pharmacology), Soybeans (chemistry), Soybeans (enzymology).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Alkylating, Coordination Complexes, Lipoxygenase, Mechlorethamine, Platinum, Prodrugs.
- chemical , metabolism : Lipoxygenase.
- chemical , pharmacology : Anti-Bacterial Agents, Antifungal Agents, Antineoplastic Agents, Alkylating, Coordination Complexes, Prodrugs.
- chemistry : Soybeans.
- drug effects : Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria.
- enzymology : Soybeans.
- growth & development : Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria.
- Microbial Sensitivity Tests.
Abstract
The reaction of K(2)PtCl(4) with anticancer-alkylating agent mechlorethamine hydrochloride (CH(3)NH(C(2)H(4)Cl)(2) x HCl = HN2×HCl), in the molar ratio 1 : 2, affords the complex [H2N2](2)[PtCl(4)]. In vitro antimicrobial and lipoxygenase inhibitory activities of the complex and its precursor were evaluated. Antimicrobial activity of the HN2×HCl and [H2N2](2)[PtCl(4)] complex was investigated against 29 species of microorganisms. Testing is performed by microdilution method. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of precursor and corresponding platinum(II) complex is noticed and the activity of the precursor was higher. Tested compounds demonstrated the high and significant antifungal activity and low to moderate antibacterial activity. It was shown that the gram-positive bacteria were more sensitive than the gram-negative. UV absorbance-based enzyme assays were performed with HN2×HCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also. Assay with LOX showed significantly greater inhibitory activity of the complex, than the precursor.
DOI: 10.2174/157340612802084315
PubMed: 22741794
Affiliations:
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Le document en format XML
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Petrovi</name></author><author><name sortKey=" Omi, Ljiljana R" sort=" Omi, Ljiljana R" uniqKey=" Omi L" first="Ljiljana R" last=" Omi">Ljiljana R. Omi</name></author><author><name sortKey="Simijonovi, Dusica" sort="Simijonovi, Dusica" uniqKey="Simijonovi D" first="Dušica" last="Simijonovi">Dušica Simijonovi</name></author><author><name sortKey="Petrovi, Vladimir P" sort="Petrovi, Vladimir P" uniqKey="Petrovi V" first="Vladimir P" last="Petrovi">Vladimir P. Petrovi</name></author><author><name sortKey="Hadjipavlou Litina, Dimitra" sort="Hadjipavlou Litina, Dimitra" uniqKey="Hadjipavlou Litina D" first="Dimitra" last="Hadjipavlou-Litina">Dimitra Hadjipavlou-Litina</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22741794</idno><idno type="pmid">22741794</idno><idno type="doi">10.2174/157340612802084315</idno><idno type="wicri:Area/PubMed/Corpus">000143</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000143</idno><idno type="wicri:Area/PubMed/Curation">000143</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000143</idno><idno type="wicri:Area/PubMed/Checkpoint">000138</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000138</idno><idno type="wicri:Area/Ncbi/Merge">000785</idno><idno type="wicri:Area/Ncbi/Curation">000785</idno><idno type="wicri:Area/Ncbi/Checkpoint">000785</idno><idno type="wicri:Area/Main/Merge">000A84</idno><idno type="wicri:Area/Main/Curation">000A82</idno><idno type="wicri:Area/Main/Exploration">000A82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.</title><author><name sortKey="Radojevi, Ivana D" sort="Radojevi, Ivana D" uniqKey="Radojevi I" first="Ivana D" last="Radojevi">Ivana D. Radojevi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, P. O. Box 60, 34000 Kragujevac, Serbia. ivana@kg.ac.rs</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, P. O. Box 60, 34000 Kragujevac</wicri:regionArea><wicri:noRegion>34000 Kragujevac</wicri:noRegion></affiliation></author><author><name sortKey="Petrovi, Zorica D" sort="Petrovi, Zorica D" uniqKey="Petrovi Z" first="Zorica D" last="Petrovi">Zorica D. Petrovi</name></author><author><name sortKey=" Omi, Ljiljana R" sort=" Omi, Ljiljana R" uniqKey=" Omi L" first="Ljiljana R" last=" Omi">Ljiljana R. Omi</name></author><author><name sortKey="Simijonovi, Dusica" sort="Simijonovi, Dusica" uniqKey="Simijonovi D" first="Dušica" last="Simijonovi">Dušica Simijonovi</name></author><author><name sortKey="Petrovi, Vladimir P" sort="Petrovi, Vladimir P" uniqKey="Petrovi V" first="Vladimir P" last="Petrovi">Vladimir P. Petrovi</name></author><author><name sortKey="Hadjipavlou Litina, Dimitra" sort="Hadjipavlou Litina, Dimitra" uniqKey="Hadjipavlou Litina D" first="Dimitra" last="Hadjipavlou-Litina">Dimitra Hadjipavlou-Litina</name></author></analytic><series><title level="j">Medicinal chemistry (Shariqah (United Arab Emirates))</title><idno type="eISSN">1875-6638</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Antifungal Agents (chemistry)</term><term>Antifungal Agents (pharmacology)</term><term>Antineoplastic Agents, Alkylating (chemistry)</term><term>Antineoplastic Agents, Alkylating (pharmacology)</term><term>Coordination Complexes (chemistry)</term><term>Coordination Complexes (pharmacology)</term><term>Fungi (drug effects)</term><term>Fungi (growth & development)</term><term>Gram-Negative Bacteria (drug effects)</term><term>Gram-Negative Bacteria (growth & development)</term><term>Gram-Positive Bacteria (drug effects)</term><term>Gram-Positive Bacteria (growth & development)</term><term>Lipoxygenase (chemistry)</term><term>Lipoxygenase (metabolism)</term><term>Mechlorethamine (chemistry)</term><term>Microbial Sensitivity Tests</term><term>Platinum (chemistry)</term><term>Prodrugs (chemistry)</term><term>Prodrugs (pharmacology)</term><term>Soybeans (chemistry)</term><term>Soybeans (enzymology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens ()</term><term>Antibactériens (pharmacologie)</term><term>Antifongiques ()</term><term>Antifongiques (pharmacologie)</term><term>Antinéoplasiques alcoylants ()</term><term>Antinéoplasiques alcoylants (pharmacologie)</term><term>Bactéries à Gram négatif ()</term><term>Bactéries à Gram négatif (croissance et développement)</term><term>Bactéries à Gram positif ()</term><term>Bactéries à Gram positif (croissance et développement)</term><term>Champignons ()</term><term>Champignons (croissance et développement)</term><term>Chlorméthine ()</term><term>Complexes de coordination ()</term><term>Complexes de coordination (pharmacologie)</term><term>Lipoxygenase ()</term><term>Lipoxygenase (métabolisme)</term><term>Platine ()</term><term>Promédicaments ()</term><term>Promédicaments (pharmacologie)</term><term>Soja ()</term><term>Soja (enzymologie)</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Antineoplastic Agents, Alkylating</term><term>Coordination Complexes</term><term>Lipoxygenase</term><term>Mechlorethamine</term><term>Platinum</term><term>Prodrugs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lipoxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antifungal Agents</term><term>Antineoplastic Agents, Alkylating</term><term>Coordination Complexes</term><term>Prodrugs</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Bactéries à Gram négatif</term><term>Bactéries à Gram positif</term><term>Champignons</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fungi</term><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Soja</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Fungi</term><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lipoxygenase</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Antifongiques</term><term>Antinéoplasiques alcoylants</term><term>Complexes de coordination</term><term>Promédicaments</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antibactériens</term><term>Antifongiques</term><term>Antinéoplasiques alcoylants</term><term>Bactéries à Gram négatif</term><term>Bactéries à Gram positif</term><term>Champignons</term><term>Chlorméthine</term><term>Complexes de coordination</term><term>Lipoxygenase</term><term>Platine</term><term>Promédicaments</term><term>Soja</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The reaction of K(2)PtCl(4) with anticancer-alkylating agent mechlorethamine hydrochloride (CH(3)NH(C(2)H(4)Cl)(2) x HCl = HN2×HCl), in the molar ratio 1 : 2, affords the complex [H2N2](2)[PtCl(4)]. In vitro antimicrobial and lipoxygenase inhibitory activities of the complex and its precursor were evaluated. Antimicrobial activity of the HN2×HCl and [H2N2](2)[PtCl(4)] complex was investigated against 29 species of microorganisms. Testing is performed by microdilution method. Minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) have been determined. The difference between antimicrobial activity of precursor and corresponding platinum(II) complex is noticed and the activity of the precursor was higher. Tested compounds demonstrated the high and significant antifungal activity and low to moderate antibacterial activity. It was shown that the gram-positive bacteria were more sensitive than the gram-negative. UV absorbance-based enzyme assays were performed with HN2×HCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also. Assay with LOX showed significantly greater inhibitory activity of the complex, than the precursor.</div></front></TEI><affiliations><list><country><li>Serbie</li></country></list><tree><noCountry><name sortKey=" Omi, Ljiljana R" sort=" Omi, Ljiljana R" uniqKey=" Omi L" first="Ljiljana R" last=" Omi">Ljiljana R. Omi</name><name sortKey="Hadjipavlou Litina, Dimitra" sort="Hadjipavlou Litina, Dimitra" uniqKey="Hadjipavlou Litina D" first="Dimitra" last="Hadjipavlou-Litina">Dimitra Hadjipavlou-Litina</name><name sortKey="Petrovi, Vladimir P" sort="Petrovi, Vladimir P" uniqKey="Petrovi V" first="Vladimir P" last="Petrovi">Vladimir P. Petrovi</name><name sortKey="Petrovi, Zorica D" sort="Petrovi, Zorica D" uniqKey="Petrovi Z" first="Zorica D" last="Petrovi">Zorica D. Petrovi</name><name sortKey="Simijonovi, Dusica" sort="Simijonovi, Dusica" uniqKey="Simijonovi D" first="Dušica" last="Simijonovi">Dušica Simijonovi</name></noCountry><country name="Serbie"><noRegion><name sortKey="Radojevi, Ivana D" sort="Radojevi, Ivana D" uniqKey="Radojevi I" first="Ivana D" last="Radojevi">Ivana D. Radojevi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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